Satellite of the 7th FENS Forum of European Neuroscience
 

Translational aspects of proteolysis in neurodegenerative diseases

1- 2 July 2010, Maastricht, The Netherlands
School of Governance, Maastricht, The Netherlands

Organizers: F.W. van Leeuwen and N. Kholod
 

Protein quality control systems are essential for neuronal function. In neurodegenerative diseases these systems are  partial dysfunctional.
In the present satellite failures of the main protein degradation systems will be discussed, their downstream consequences for synaptic plasticity and strategies for therapy. Translational aspects for combating these diseases will be presented.
 

Welcome reception

J.J. Lucas (Centro de Biologia Molecular "Severo Ochoa", CSIC/UAM. Madrid, Spain)
The ubiquitin-proteasome system in Huntington’s disease

H. Paulson (University of Michigan, Ann Arbor, USA) - Sigma-Aldrich lecture
Protein quality control in polyglutamine neurodegenerative diseases: insights leading toward therapies


F.W. van Leeuwen (Maastricht University, Maastricht, The Netherlands)
Misframed ubiquitin in tauopathies and polyglutamine diseases; interactions with Aβ plaque formation and intranuclear inclusions

Lunch break

D.C. Rubinsztein (University of Cambridge, Cambridge, UK)
Autophagy, aggregates and neurodegeneration

K. Kosik** (University of California Santa Barbara, USA)
Tau degradation pathways and opportunities for intervention in Alzheimer's disease
** ISAO lecture

S. M. Wilson (University of Alabama at Birmingham, Birmingham, USA)
Synaptic dysfunction and the ubiquitin-proteasome system
 

Scientists can present their data in poster form and may be invited to present their data briefly (on basis of their abstract) upon which the invited speakers will comment.
 

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