|
|
|
|
Legend: Scheme of computer model of energy-transduction in muscle cells. ATP is the central molecule which provides energy for muscle contraction. The ATPases are the enzymes using ATP to bring about contraction. Oxidative phosphorylation (OxPhos) is the process which produces ATP in the mitochondria. Our model focusses on the role of the creatine kinase (CK) enzymes. Two different forms of creatine kinase exist: one is found in the intermembrane space of the mitochondria; the second form is found near the contractile elements. Our model concentrates on the role of the CK forms in transporting energy-rich phosphate groups through the muscle cell, and on the other hand mediating signals that ATP needs to be resynthesized. In a project funded by the European Union, we started to develop a computer model of dynamic energy metabolism. The main scientist on this project is Olav Kongas, who returned to the Institute for Cybernetics in Tallinn, Estonia, on May 2002. His e-mail address there is : kongas@ioc.ee A description of some of the first results can be found in on the web: International Conference of Systems Biology ICSB 2001. The resulting computer model is available at: http://cens.ioc.ee/~kongas/model_download/main.html Key elements
|
You can contact me by e-mail at hvanbeek@bio.vu.nl.
|
![[Under construction]](images/undercon.gif){kind=small}
